As long as you are confident with the shot (I was, had shot steel plates and milk jugs 3 out of 3 with consecutive shots at 300 yards, so I knew how much to dial up and that the rifle could easily do it.) As long as you have a safe backstop and the shot was safe (fox was in the middle of a field midway up a large hill.) Then I see no problems with taking the shot, there was no wind I might add and I probably wouldn't have taken the shot if there had been a good wind, as I haven't yet got a wind meter for calculating precise windage, I'd rather leave it be than injure it. It is very satisfying making a kill at that distance though but I wont make a habit of it and don't plan on doing it that far again.