SpringDon Posted July 31, 2020 Report Share Posted July 31, 2020 22 minutes ago, 7daysinaweek said: That taste and nausea is from from the production of raised levels of 'catecholcolomines' these are collectively known as 'adrenaline' and there are several types of hormone produce in the 'fight and flight response.' Some mechanisms of these 'agonists' inhibit salivary production in the response. Interesting. I wondered if there was something specific about hormone released when a bone breaks, it seems strange to get a physiological response before the pain. And, whilst we’re on the subject, why does pain have to hurt so much? Mild discomfort would be enough to pass the message. I model my self on the terminator - “I don’t feel pain; just the input of data”. Except it doesn’t help at all. Quote Link to comment Share on other sites More sharing options...
7daysinaweek Posted July 31, 2020 Report Share Posted July 31, 2020 (edited) 2 hours ago, SpringDon said: Interesting. I wondered if there was something specific about hormone released when a bone breaks, it seems strange to get a physiological response before the pain. And, whilst we’re on the subject, why does pain have to hurt so much? Mild discomfort would be enough to pass the message. I model my self on the terminator - “I don’t feel pain; just the input of data”. Except it doesn’t help at all. Hi Springdon Pain and pain syndromes are one of the the most complex subjects in modern medicine and just to even scratch the surface in relation to your question is not an easy subject. If the response from pain receptors was limited to a narrow margin the pain response would not reflect the physiological and biochemical acute and chronic changes to that area or the increasing damaged level to the organ, tissue, muscle or bone. Firstly pain innervation signals tell our brain that something is damaged, the more damage that occurs the more pain receptors are involved and the more the receptor response tells the brain that an increase in noninflammatory cytokines as part of the immune response are needed along with many other hormones. Such hormones and chemicals like endogenous endorphins which help to reduce the pain after the first initial heightened signal, anti clotting agonists and antagonists in the result of bleeding and many other chemicals that will be mobilised to restore 'normality' (Homeostasis). To put simply a wider pain response field from the body is the mechanism as to which the homeostatic helping response from the body is gauged in what is required. (A fire in a waste basket may require one person with a cup of water to tackle it , a blazing inferno in a building will require more people to raise the alarm, fire engines and several people with water, foam, breathing equipment etc so much more resources) Pain response is also a evolutionary protective mechanism, you stubb your toe and in most cases the 'air turns blue' for a few seconds and then you carry on. You break a bone and you are more likely to not move that bone. This level of pain also psychologically influences us to keep still until the body can make attempts at healing. Modern medicine has allowed us a diagnostic and treatment avenue that can hopefully help the body in healing quicker. A child burns themselves by touching a hot implement, they soon learn that this produces pain and is hard wired into the protective neurological mechanisms of our brain. The evolution of this mechanism is to protect ourselves a multicellular organism, all organisms want to live and reproduce. If we did not have pain response mortality and morbidity would be huge and our ability to reproduce and progress a species would be hindered. Pain receptors (nociceptors) of which there are primary ones which respond to trauma, pressure and chemical changes which tell the secondary receptors in the spinal cord which travel up to the higher centres in the brain. Visceral (organ) pain receptors innervate to a higher centre in the brain than many peripheral receptors. If your body sustained a superficial epidermal small laceration ( a cut to the finger that would not require stitching) Conversely if you developed acute appendicitis the pain you would feel would be greater than the pain from the finger cut and the homeostatic feedback response to the brain would be greater, thus the physiological and biochemical response from the brain to attempt to limit the infective inflammatory response to the damaged organ would be greater. Pain is subjective and each persons threshold within reason is different, 'pain is what the person says it is', pain is both physical, psychological and emotional, if pain encompasses these aspects it can be termed as 'whole pain'. Whole pain can be both acute and chronic. Pain is a extremely complex subject, speak to a pain specialist or a neurologist and the mind boggles. Keep safe and well. "I'LL BE BACK" atb 7diaw Edited July 31, 2020 by 7daysinaweek Quote Link to comment Share on other sites More sharing options...
Scully Posted July 31, 2020 Author Report Share Posted July 31, 2020 Fascinating stuff! How you keep all that stuff in your head I have no idea! I’m a bit Homerish....’ new information going in pushes old stuff out!’ My OH reckons I shouldn’t poke in my ears in case I dislodge the one brain cell she claims I possess. 😂 You have my utmost admiration and respect. 👍 Quote Link to comment Share on other sites More sharing options...
Old farrier Posted July 31, 2020 Report Share Posted July 31, 2020 Some horror stories here good that you have survived to tell the tale pain receptors are funny things and we all have different levels and tolerance to it had a few knocks scrapes and scratches finding each to be totally different proberably the worst of them was a medical issue causing my fingers to go a bit gammy the pain was a bit wearing so in the end I cut it off myself You don’t want to see the picture 🤔 Quote Link to comment Share on other sites More sharing options...
Mice! Posted July 31, 2020 Report Share Posted July 31, 2020 Funnily enough talking about pain has made me laugh and remember something funny that happened with my old fella, he had a lot of operations on his legs over the years from us being kids to adults and just got on with it. I took him for an appointment once in Trafford, I think it was for a cortisone injection, imagine the waiting room from hell, everyone lined up in a corridor and you can hear the people going in screaming out loud!! 5 or 6 go in and come out before it's my old fellas turn, few minutes go by with no sound then out he comes and away we walk, big grin on his face? Once out of ear shot I say how hard are you not a sound! Yes he says I didn't get the shot, apparently he had had too many in twelve months to get another yet 😆😆 Quote Link to comment Share on other sites More sharing options...
7daysinaweek Posted July 31, 2020 Report Share Posted July 31, 2020 38 minutes ago, Scully said: Fascinating stuff! How you keep all that stuff in your head I have no idea! I’m a bit Homerish....’ new information going in pushes old stuff out!’ My OH reckons I shouldn’t poke in my ears in case I dislodge the one brain cell she claims I possess. 😂 You have my utmost admiration and respect. 👍 👍 19 minutes ago, Old farrier said: Some horror stories here good that you have survived to tell the tale pain receptors are funny things and we all have different levels and tolerance to it had a few knocks scrapes and scratches finding each to be totally different proberably the worst of them was a medical issue causing my fingers to go a bit gammy the pain was a bit wearing so in the end I cut it off myself You don’t want to see the picture 🤔 Sounds like it became necrotic O.F 18 minutes ago, Mice! said: Funnily enough talking about pain has made me laugh and remember something funny that happened with my old fella, he had a lot of operations on his legs over the years from us being kids to adults and just got on with it. I took him for an appointment once in Trafford, I think it was for a cortisone injection, imagine the waiting room from hell, everyone lined up in a corridor and you can hear the people going in screaming out loud!! 5 or 6 go in and come out before it's my old fellas turn, few minutes go by with no sound then out he comes and away we walk, big grin on his face? Once out of ear shot I say how hard are you not a sound! Yes he says I didn't get the shot, apparently he had had too many in twelve months to get another yet 😆😆 "Cool as a cucumber'" K Quote Link to comment Share on other sites More sharing options...
Pistol p Posted July 31, 2020 Report Share Posted July 31, 2020 I took my mum to hospital with broken ulna and radius bones in her left arm. The doctors set, re broke and rest the fractures three times over nine hours and she didn't make a fuss at all. Fair enough she was on gas, but she was home and happy that night no trauma. Shes 90 next week and hard as concrete. Quote Link to comment Share on other sites More sharing options...
Old farrier Posted July 31, 2020 Report Share Posted July 31, 2020 2 hours ago, 7daysinaweek said: 👍 Sounds like it became necrotic O.F "Cool as a cucumber'" K Just a tad bit of a cross between frostbite and gangrene Quote Link to comment Share on other sites More sharing options...
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