welsh1 Posted March 28, 2023 Report Share Posted March 28, 2023 An article in the mail today about being immune to opiods. About 10 years ago i was in bad pain from snapped ACL and a disc crumbling in my back, the doctor prescribed Oromorph and told me to start on 5ml and increse the dose to control the pain, a few weeks later i went back, he asked how much i was taking and when i told him 80ml and the pain was still there he told me to stop as i would not wake up one day. I had continued to work and drive 1500 miles a week. The doctor sent me to a pain specialist, she asked what i took for a headache, i told her asprin, she asked why not paracetamol and i told her it never worked. She stuck a morphine patch on my arm and told me to come back in a week, she also told me i may just sit in a chair all week and sleep, a week later having gone to work and driven the usual 1500 miles i went back. I was told that my body worked slightly different and i was one of 17% who were opioid immune, opioids just did not work on my pain, some make me feel sea sick, some give me a very upset gut, but none stop pain. Before all this i was one admitted to hospital with kidney stones, the doctor gave me 10ml of morphine, then upped it to 20ml and all the while i kept telling them it wasn't stopping the pain, they must have thought i was a right whinging junkie lol.https://www.dailymail.co.uk/health/article-11908101/Strong-painkillers-barely-worked-agonising-knee-surgery.html Quote Link to comment Share on other sites More sharing options...
ditchman Posted March 28, 2023 Report Share Posted March 28, 2023 not at all surprised....there are 2 meds that i believe i am immune to...one of them does nothing for me ...the other one just makes me queasy........ Quote Link to comment Share on other sites More sharing options...
mr smith Posted March 28, 2023 Report Share Posted March 28, 2023 Has two shots of morphine don't know the dose when i went in to a&e with what turned out to be gallstones, didn't make a blind bit of difference and the guy was surprised when I asked for another after the first. Quote Link to comment Share on other sites More sharing options...
Houseplant Posted March 28, 2023 Report Share Posted March 28, 2023 https://www.cebm.ox.ac.uk/resources/ebm-tools/number-needed-to-treat-nnt#:~:text=Definition-,The Number Needed to Treat (NNT) is the number of,prevent one additional bad outcome. Quote Link to comment Share on other sites More sharing options...
welsh1 Posted March 28, 2023 Author Report Share Posted March 28, 2023 1 hour ago, Houseplant said: https://www.cebm.ox.ac.uk/resources/ebm-tools/number-needed-to-treat-nnt#:~:text=Definition-,The Number Needed to Treat (NNT) is the number of,prevent one additional bad outcome. Isn't that different from being immune to the opiate? From what i see in your chart this is a calculation for how many are treated to prevent a bad outcome with the given drug. My problem is that no matter how much you give me of an opiate i won't have any pain relief, it may kill me but it won't be painless lol. Quote Link to comment Share on other sites More sharing options...
JohnfromUK Posted March 28, 2023 Report Share Posted March 28, 2023 (edited) Interesting. I don't think I'm immune to opioids ....... because I was given an (I believe opioid) injection in the backside by the Dr many years ago for a kidney stone - and it worked a charm until it wore off! However, I don't get any relief from the usual dental injections and still feel every turn of the drill. This despite being given multiple injections. When I have had miinor operations (non dental) under local, that has always worked fine, so I assume dental anaesthetic is different? When I was a child I had several tooth removals under general (gas) and remember feeling every bit of that, but I had a long (1 3/4 hours) and complex wisdom tooth removal involving bone removal in hospital under (non gas) general and that worked a dream. Edited March 28, 2023 by JohnfromUK Quote Link to comment Share on other sites More sharing options...
Houseplant Posted March 28, 2023 Report Share Posted March 28, 2023 1 hour ago, welsh1 said: Isn't that different from being immune to the opiate? From what i see in your chart this is a calculation for how many are treated to prevent a bad outcome with the given drug. My problem is that no matter how much you give me of an opiate i won't have any pain relief, it may kill me but it won't be painless lol. Number needed to treat neatly summarises the concept that medicine is somewhat population based rather than bespoke to the individual patient. For any given drug, you need to treat a number of people before you see the benefits in one person. It's a medical way of saying that not all drugs work for everybody. We know that already, but thanks to the Daily Mail for the reminder. Quote Link to comment Share on other sites More sharing options...
shaun4860 Posted March 28, 2023 Report Share Posted March 28, 2023 3 hours ago, JohnfromUK said: Interesting. I don't think I'm immune to opioids ....... because I was given an (I believe opioid) injection in the backside by the Dr many years ago for a kidney stone - and it worked a charm until it wore off! However, I don't get any relief from the usual dental injections and still feel every turn of the drill. This despite being given multiple injections. When I have had miinor operations (non dental) under local, that has always worked fine, so I assume dental anaesthetic is different? When I was a child I had several tooth removals under general (gas) and remember feeling every bit of that, but I had a long (1 3/4 hours) and complex wisdom tooth removal involving bone removal in hospital under (non gas) general and that worked a dream. I’m sort of the same regarding dental injections. I needed some work done and in went the first injections. Could still feel everything After numerous more injections he said I can’t give you anymore you had the maximum so I left. About 10 that night the whole of my mouth went totally numb. Was ok the next morning. Told dentist and he brought me in early for my next appointment, filled me with injections and sat me back in the waiting room for a couple of hours. Got there in the end Quote Link to comment Share on other sites More sharing options...
welsh1 Posted March 28, 2023 Author Report Share Posted March 28, 2023 3 hours ago, JohnfromUK said: Interesting. I don't think I'm immune to opioids ....... because I was given an (I believe opioid) injection in the backside by the Dr many years ago for a kidney stone - and it worked a charm until it wore off! However, I don't get any relief from the usual dental injections and still feel every turn of the drill. This despite being given multiple injections. When I have had miinor operations (non dental) under local, that has always worked fine, so I assume dental anaesthetic is different? When I was a child I had several tooth removals under general (gas) and remember feeling every bit of that, but I had a long (1 3/4 hours) and complex wisdom tooth removal involving bone removal in hospital under (non gas) general and that worked a dream. 19 minutes ago, shaun4860 said: I’m sort of the same regarding dental injections. I needed some work done and in went the first injections. Could still feel everything After numerous more injections he said I can’t give you anymore you had the maximum so I left. About 10 that night the whole of my mouth went totally numb. Was ok the next morning. Told dentist and he brought me in early for my next appointment, filled me with injections and sat me back in the waiting room for a couple of hours. Got there in the end After i found out i was immune to opiods i did a bit of googling and looking for information, there are some who like yourselves need a bit more of the stuff than normal, it's all to do with your genes.https://norwegianscitechnews.com/2016/07/50000-norwegians-require-more-morphine-than-the-average-joe/ Quote Link to comment Share on other sites More sharing options...
Gordon R Posted March 28, 2023 Report Share Posted March 28, 2023 My eldest broke his back at motocross some years ago. Air-lifted to Blackpool Hospital, where he was given Morphine. His arm ballooned up and they had to give him something to counteract the Morphine. Allergic to the stuff. Quote Link to comment Share on other sites More sharing options...
welsh1 Posted March 28, 2023 Author Report Share Posted March 28, 2023 3 minutes ago, Gordon R said: My eldest broke his back at motocross some years ago. Air-lifted to Blackpool Hospital, where he was given Morphine. His arm ballooned up and they had to give him something to counteract the Morphine. Allergic to the stuff. He should get a medi bracelet, it would let medics know his allergy if something happened in the future, if i am out on the bike i wear one because of the morphine resistance and i am also allergic to penicillin. Quote Link to comment Share on other sites More sharing options...
Jaymo Posted March 28, 2023 Report Share Posted March 28, 2023 5 hours ago, welsh1 said: My problem is that no matter how much you give me of an opiate i won't have any pain relief, it may kill me but it won't be painless lol. Welcome to my world. I would make a bloody useless junkie. That, or it’s gonna cost me considerably more for the same effect on others. Quote Link to comment Share on other sites More sharing options...
welsh1 Posted March 28, 2023 Author Report Share Posted March 28, 2023 1 minute ago, Jaymo said: Welcome to my world. I would make a bloody useless junkie. That, or it’s gonna cost me considerably more for the same effect on others. Look at NSAIDs for pain relief, they are by no means the best but do work on limiting some pain, asprin are in this group. Quote Link to comment Share on other sites More sharing options...
ditchman Posted March 28, 2023 Report Share Posted March 28, 2023 1 hour ago, shaun4860 said: I’m sort of the same regarding dental injections. I needed some work done and in went the first injections. Could still feel everything After numerous more injections he said I can’t give you anymore you had the maximum so I left. About 10 that night the whole of my mouth went totally numb. Was ok the next morning. Told dentist and he brought me in early for my next appointment, filled me with injections and sat me back in the waiting room for a couple of hours. Got there in the end same happened to me.........go in get theinjections ...nothing....sat me in the waiting room for an hour whilst he saw other patients...then called me in ...and i was good to go ! Quote Link to comment Share on other sites More sharing options...
Vince Green Posted March 30, 2023 Report Share Posted March 30, 2023 A slightly different story, years ago I worked with a man called Jack who went into hospital to have an operation on a tendon in his elbow. They gave him the anaesthetic and he immediately went into arrest and died. They couldn't resuscitate him despite being surrounded by doctors. He had a massive reaction to the anaesthetic, some people do apparently. That's the opposite end of the scale to being immune. About a year later at the same place one of the secretaries died from a bee sting. Quote Link to comment Share on other sites More sharing options...
JohnfromUK Posted March 30, 2023 Report Share Posted March 30, 2023 2 minutes ago, Vince Green said: He had a massive reaction to the anaesthetic, some people do apparently. I think they can now test for it in advance. Some years ago, my late father had a hip replacement, which was done under 'epidural' which as I understand it is a sort of 'partial' anaesthetic. Before he could have this he was tested - and I'm pretty sure that was to check for his 'compatibility' with the anaesthetic - which he had not had before. He was fine and the op went well. Quote Link to comment Share on other sites More sharing options...
Houseplant Posted March 30, 2023 Report Share Posted March 30, 2023 2 hours ago, Vince Green said: A slightly different story, years ago I worked with a man called Jack who went into hospital to have an operation on a tendon in his elbow. They gave him the anaesthetic and he immediately went into arrest and died. They couldn't resuscitate him despite being surrounded by doctors. He had a massive reaction to the anaesthetic, some people do apparently. That's the opposite end of the scale to being immune. Probably malignant hyperthermia (risk 1:100 000) or drug anaphylaxis (risk 1:20 000), most likely a muscle relaxant or antibiotic rather than an anaesthetic drug per se. Alternatively, cardiovascular collapse due to a combination of the anaesthetic and pre-existing cardiac disease. Sadly, not everyone can be resuscitated. Quote Link to comment Share on other sites More sharing options...
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